ABSTRACT
Objective: The present study evaluates anti-microbial effect of hydrogel formulated with the extracts of some indigenous drugs against Propionibacterium acne. Material and Method: Procured Manjishtha (Rubia Cordifolia L.), Shalmali (Salmalia malabarica (DC. Schott & Endl) Schott & Endl.), Daruharidra (Berberis aristate DC), Aloe vera (Aloe barbadensis Miller), Yashthimadhu (Glycyrrhiza glabra L). Extracts of all drugs except Aloe vera were collected by hydroalcoholic extraction using the Soxhlet apparatus. Aqueous extract of Aloe vera was collected by drying method. Two types of hydrogels were prepared with the extracts of these drugs, one with 5% extract and the other with 10% extract. Propionibacterium acne strains were collected from CSIR-Imtech Chandigarh. Culturing of bacteria was done by using nutrient broth. Nutrient agar was used for preparing the culture media. The antibacterial efficacy of the hydrogels was evaluated by comparing them with standard gentamycin. Result: The prepared hydrogel showed an anti-bacterial effect, but it is comparatively less when compared with the standard gentamycin. Conclusion: The prepared gel has anti-microbial activity. 10% hyrdogel showed better results than 5% hydrogel.
ABSTRACT
Wound is a break in the integrity of the skin or tissue often, which may be associated with disruption of the structures and functions. Wound healing is a complex series of events that begin when an individual gets affected by a wound. It is a mechanism whereby the body attempts to re-establish the integrity of the injured part. In modern biomedical sciences, research on wound healing agents is one of the developing areas. Natural compounds are used in skin wound care from many years due to their therapeutic activities, including anti-inflammatory, antimicrobial, and cell-stimulating properties. Various herbs, oils and natural resources have been described in Ayurveda with wound healing properties. Acharya Sushruta has explained many drugs and formulations for the treatment of Vrana (wound). One such formulation named Ropana Taila has been described in Sushsruta Samhita for Wound healing. The present review article is undertaken to discuss about the wound healing activity of Ropana Taila
ABSTRACT
RTI (Reproductive Tract Infection) is the vital cause of suffering in women and neonates. According to WHO estimation 340 million new cases of curable STI (Sexually Transmitted Disease) other than HIV/AIDS occurs every year, most of which are occurring in developing countries. Genital tract infection is the prime cause of most gynaecological disease. Vaginal candidiasis is the most common cause of Genital tract infection. It (Vaginal candidiasis) is a common condition and up to 75% of all women suffer at least one episode of this infection during their life time. For treating the pathological condition of genital tract, direct application or self application of medicine is very difficult and the residence time of the medicine is less due to self cleansing properties of vaginal canal. Application of the drug in other route may cause systemic adverse reaction. To overcome this arduous situation, in situ thermo-sensitive gel form has great importance. In this article an attempt have been made for the review of the thermo-sensitive vaginal gel and the scholar has gathered the basic knowledge to develop an Ayurvedic formulation Panchavalkal kashaya thermo-sensitive vaginal gel by this review. This work will be done in School of Pharmaceutical Science, Shoolini University, Solan, HP.